Leigh are set to be without prop Rob Parker for the rest of the season with a finger injury.
Head Coach Paul Rowley said: “Rob’s having an operation on his finger on Friday, and that’s probably his season done.
“It’s a big blow for us. We’ll be lucky if we get another game out of him this year.”
A win over Halifax could lift Leigh up to third in the table, and the Centurions have beaten their Yorkshire opponents three times already this term.
Duffy’s absence means he misses out on the chance to make his 200th appearance for the club.