Brad Singleton is expected to miss four months of action for Toronto after rupturing the lateral medial ligament in his knee.
Singleton, 27, has scored one try in four appearances for the Wolfpack, and will undergo surgery in the coming days and is expected to miss four months.
Jon Wilkin will put his knee surgery on hold, and is expected to play against St Helens at the Halliwell Jones Stadium this Saturday.
Gadwin Springer returns to the team after passing the concussion protocol, while Darcy Lussick is expected to play after recovering from hernia surgery.
Joe Mellor, who injured his hand in round two against Salford, is expected to return within the next two weeks, and Chase Stanley is hoping to arrive in the UK next week after visa issues.
Watch our Last Tackle podcast, featuring a guest, every week. SUBSCRIBE to Love Rugby League on YouTube.