Warrington centre Connor Wrench will be out for up to five weeks with a stress fracture in the back.
Wrench, 20, stood in for the injured Toby King against Leeds but sat out the win over Castleford.
Coach Daryl Powell said: “He’s got a stress fracture in there which is probably going to keep him out for between four or five weeks which is obviously disappointing for him.
“He looked sharp against Leeds and, although we’ve got Toby King back, I’m looking forward to seeing how he grows this year.”
Connor Wrench made a handful of Super League appearances last season and had a spell on loan at Newcastle Thunder.
He was called up to the England squad as a travelling reserve for the test match with France back in October.
The Wolves are in France themselves this weekend for a first ever competitive meeting with Toulouse.
Back-rower Ben Currie is also sitting that out due to a sternum injury, but should be fit for next week’s home game against Catalans.
Oliver Holmes remains suspended, but both Daryl Clark and Mike Cooper are set to return.
Toulouse could hand a debut to former Widnes full-back Oliver Ashall-Bott, who they signed from Huddersfield earlier this week.
Although it’s the first competitive meeting between the two sides, they have played against each other before.
Toulouse travelled to the Halliwell Jones Stadium back in January 2015, and beat the Wolves 26-6.
That game was prior to Toulouse’s return to the RFL pyramid.
Joe Philbin played for a youthful Wolves side in that game, the only survivor from Tony Smith’s squad.
The Warrington team also included the likes of Gary Wheeler, Ben Harrison, Dec Patton and Harvey Livett.
Current Toulouse winger Matty Russell played for the Wolves that day too, as did now Salford hooker Andy Ackers.