The full-back, who is returning to the UK from the NRL to play for Wigan in 2016, has not fuly recovered from a knee injury he sustained earlier this season.
“We wanted to give him every chance to confirm his fitness but it wasn’t to be.
“Sam is devastated to miss out. He was looking forward to the month ahead with England and making a huge impact.
“His recent rehabilitation programme was designed to give him the best chance of a full recovery and playing for England, but the important thing now is for him to have the injury re-assessed and to get himself ready for full fitness as soon as possible.”