Five players are set to make their debuts for London on Sunday, while Wakefield are set to start new recruit Danny Brough.
London head coach Danny Ward is set to hand out competitive debuts to new signings Luke Yates, Ryan Morgan, Nathan Mason, Greg Richards and Matty Fozard.
The Broncos will take part in Super League for the first time since 2014 following their promotion from the Championship last season.
Wakefield Trinity coach Chris Chester could hand out debuts to Brough, George King and Craig Kopczak.
All three have international experience with Scotland, Ireland and Wales respectively.
The Super League round one fixture takes place at Trailfinders Sports Club on Sunday, 3pm kick-off.
Drew’s dabble: Wakefield are priced at 4/1 to win by 21-30 points, nice odds.
London’s 19-man squad: Jordan Abdull, Sadiq Adebiyi, Eddie Battye, James Cunningham, Kieran Dixon, Matt Fleming, Matty Fozard, Matt Gee, Mark Ioane, Elliot Kear, Will Lovell, Nathan Mason, Ryan Morgan, Eloi Pelissier, Jay Pitts, Greg Richards, Alex Walker, Rhys Williams, Luke Yates.
Wakefield’s 19-man squad: Tinirau Arona, Joe Arundel, Matty Ashurst, James Batchelor, Danny Brough, Jordan Crowther, Anthony England, David Fifita, Ryan Hampshire, Justin Horo, Tom Johnstone, Ben Jones-Bishop, George King, Craig Kopczak, Reece Lyne, Jacob Miller, Tyler Randell, Bill Tupou, Kyle Wood.