Hull FC will welcome back half-back pair Marc Sneyd and Albert Kelly on Friday, while Castleford have dropped Greg Eden.
Lee Radford has made five changes to his Hull FC side that lost to Catalans last week. Sneyd, Kelly, Cameron Scott, Dean Hadley and Ratu Naulago come in for Liam Harris, Connor Wynne, Jordan Thompson, Levy Nzoungou and Kieran Buchanan.
Castleford coach Daryl Powell has made four changes to his Tigers outfit that were defeated by Warrington last time out. James Clare, Jesse Sene-Lefao, Matt Cook and Jordan Rankin are back in the squad.
Paul McShane and Daniel Smith miss out through injury, while Eden and Lewis Peachey have been dropped.
The televised Challenge Cup match takes place at the KCOM Stadium on Friday night, 7:35pm kick-off.
Drew’s dabble: Castleford are priced at 13/2 to win the game by 1-5 points.
Hull’s 19-man squad: Bureta Faraimo, Josh Griffin, Albert Kelly, Marc Sneyd, Scott Taylor, Danny Houghton, Dean Hadley, Mark Minichiello, Joe Westerman, Jake Connor, Chris Green, Masi Matongo, Brad Fash, Sika Manu, Mickey Paea, Jack Logan, Cameron Scott, Ratu Naulago, Gareth Ellis.
Castleford’s 19-man squad: Cory Aston, Cheyse Blair, James Clare, Mitch Clark, Chris Clarkson, Matt Cook, Tuoyo Egodo, Will Maher, Nathan Massey, Peter Mata’utia, Mike McMeeken, Adam Milner, Greg Minikin, Jacques O’Neill, Jordan Rankin, Jesse Sene-Lefao, Jake Trueman, Calum Turner, Liam Watts.