The fixtures were announced on Monday, and the new Welsh side will face the Cumbrian former Super League club on February 28.
Executive chairman of Wales Rugby League and one of the South Wales’ club’s directors Mark Rowley said: “We’re looking forward to the first game on February 28th which we’re delighted to see is at home. We anticipate that we will get a good crowd as there has been a lot of excitement regarding our launch.
“We have an enormous player base to call on in South Wales now so I know that we have the structure down here to be very competitive.”
The club, who will be playing their home games out of the famous Gnoll ground in Neath, will only play league matches in their inaugural season and will enter the Northern Rail Cup and Carnegie Challenge Cup from 2011 onwards.
Their most local match will be against London Skolars on March 28.