The Robins travel to Odsal on the back of a defeat to Castleford, while Bradford have won eight consecutive Championship games.
Lowes is anticipating ruck speed, in particular, to be raised in the Challenge Cup clash.
“The speed of the ruck will be completely different next week, it will be a faster game,” he told his club’s official website.
“We will need to deal with it and ensure we play to our strengths. If we do that then anything is possible.
“One thing is for sure, we are relishing the challenge and I am sure our supporters are too.”
Lowes was delighted with the way his team played against London, with them winning 28-2. He was particularly pleased with the fact that London scored no tries.
“I thought, defensively, we were solid,” he added.
“We were forced to defend our own line on a number of occasions but we let nothing through – and we were strong going forward against a good London side.
“Our attitude in training had been fantastic all week leading up to the game and that showed.
“We worked really hard and we came away as deserved victors, maintaining our winning run.”