The Warriors, who defeated Leeds on Tuesday night, had no answer to a clinical performance from Huddersfield who move above Salford in the Super League ladder, having been written off by many just 3 weeks ago.
It was always harsh on the Giants, who lost by less than 8 points in all of their opening 7 matches. They took the lead in this one through Brad Drew, but were almost immediately pegged back by Thomas Leuluai.
A Chris Thorman penalty on 20 minutes edged the home side in front, before David Vaealiki gave Wigan the lead on the half hour. But, crucially, just before the break , Eorl Crabtree and Stephen Wild crossed for tries, making the score 18-10 at half time to the Giants.
The game was a wrestle for the first ten minutes of the second half, but the Giants pulled away with two quick scores from Paul Reilly and Ryan Hudson which sealed the win, Thorman landing a penalty in between those two scores.
Vaealiki scored his second try of the afternoon to reduce the deficit to 34-16, but a comeback was never on the cards as Thorman slotted home a one pointer, before he completed an impressive kicking display by converting Steve Snitch's try in the last ten minutes to seal a 41-16 victory.