Both Salford owner Dr Marwan Koukash plus Harris’ now former club Wigan have confirmed the move, with Koukash stating that Noble has been offered the position of Football Director.
The shake-up is due to be announced on Monday, with the Wales head coach departing his post as assistant at the DW Stadium to take up the reigns from Noble, who was only appointed 12 months ago, and is still under contract until the end of 2014.
Assistant Andy Hay and coaching consultant Sean Long are set to remain, with former Cronulla coach Shane Flanagan also set to join the club.
Koukash said: “Iestyn Harris will become the Head coach as from Monday.
“Brian Noble has been offered the position of Director of Football. We hope he will accept to continue with his excellent work.
“Discussions also continue to bring Top NRL coach Shane Flanagan to the Red Devils as a coaching consultant, hope to progress next week.
“Noble, Harris, Flanagan , Long and Hay would be a great team to help deliver success.”
In a series of tweets, Koukash also revealed that his wife Mandy, who recently failed in a bid to buy Bradford Bulls, will spend her money on bringing more players to Salford if Harris needs them.