The 24-man squad includes 15 players from last year’s International Series win against New Zealand and four uncapped players.
Former Leeds Rhinos fullback Zak Hardaker, Hull FC number one Jamie Shaul, Wigan halfback Matty Smith and St Helens James Roby were all overlooked.
Warrington Wolves’ Daryl Clark and Stefan Ratchford, South Sydney Rabbitohs forward George Burgess, Wigan Warriors centre Dan Sarginson and Widnes Vikings’ Kevin Brown all return to the national side after missing selection in previous years.
England coach Wayne Bennett, said: “There’s been a lot of competition for places this year and the players that have been picked are the ones we believe will stand up to the test of the competing nations.
“I’ve always said that there wouldn’t be too many changes when I arrived and there are plenty of guys in the squad who worked hard in last year’s International Series win against New Zealand who have gone on and performed in 2016.
“To have Sam Burgess back is not just a boost for England but one for the international game. Having worked with him in the past, he’s a great bloke to have around and have by your shoulder on the field.
“Injuries are part and parcel of the game and to lose players like O’Loughlin, Tomkins and Currie isn’t ideal but it does offer opportunities to others who have performed in the year and it’s good to see some new and returning faces in the squad.
“There’s some serious talent in this English side and that’s testament to the England programme, the clubs they play for and the player’s attitude in wanting to do their best each week.
“I’ve spoken to the boys and they’re well aware what’s ahead of them in this tournament.”
Full 2016 Ladbrokes Four Nations schedule is as follows:
Friday October 28 (8.00pm): Australia v Scotland, Lightstream Stadium, Hull
Saturday October 29 (2.30pm): England v New Zealand, The John Smith’s Stadium, Huddersfield
Saturday November 5 (5.30pm): England v Scotland, Ricoh Arena, Coventry
Saturday November 5 (8.00pm): New Zealand v Australia, Ricoh Arena, Coventry
Friday November 11 (8.00pm): New Zealand v Scotland, The Zebra Claims Stadium, Workington
Sunday November 13 (2.00pm): England v Australia, The London Stadium, Queen Elizabeth Olympic Park, London
Sunday November 20 (2.30pm): Final, Anfield, Liverpool
All of England’s Ladbrokes Four Nations matches will be shown live on the BBC.
Thomas Burgess (South Sydney Rabbitohs, Dewsbury Moor)