Jordon Kahu replaces Jack Reed in the centres and new signing James Roberts fills the boots of recently retired club legend Justin Hodges. Kiwi Kodi Nikorima starts in the halves with Ben Hunt unavailable through suspension.
McGuire returns on the bench for his first game after rupturing his Achilles tendon in June last year.
It will be the first time McGuire has played off the bench in almost three years, his most recent interchange start in Round 14 of the 2013 season.
On the bench Travis Waddell has grabbed the utility spot, with former Bulldog Herman Ese’ese and Tom Opacic named on an extended six-man interchange list.
Broncos team to play Wigan:
Coach: Wayne Bennett