Leigh will host Widnes in the semi-finals of the 1895 Cup for a place at Wembley.
The last two teams to be relegated from Super League clash at Leigh Sports Village on Sunday July 28, the third meeting between the two sides this season.
After their administration earlier this year, it is the Vikings’ only chance of silverware this season while the Centurions won’t have given up on hopes of promotion back to the top flight.
Widnes won through comfortably on Wednesday night, beating Dewsbury 54-6, but Leigh needed a late Martin Ridyard penalty to see off Barrow 19-18.
In the other-semi final, Sheffield will host Batley.
Batley won a golden point thriller at York on Wednesday, thanks to Louis Jouffret’s extra time drop goal, while Sheffield fought from 28-12 down to beat Doncaster 32-28.
The Bulldogs have never played at Wembley, despite being the first ever winners of the Challenge Cup way back in 1897.
Sheffield of course played in arguably the most famous final of all time, when they shocked Wigan in 1998.
The final will be played at Wembley immediately after the Challenge Cup final on August 24.