The former dual-code international has been in charge of the Wales national team since September 2009, leading them to European Cup glory in 2009 and 2010, the 2011 Four Nations and the 2013 World Cup.
“I had already made this decision before taking the role at Salford but this news will now allow me to concentrate fully on being a head coach for a Super League club on a day to day basis.”
WRL Board Member Chris Thair said: “Iestyn Harris has been a consummate professional as Head Coach of Wales Rugby League and we have all enjoyed some fantastic sporting moments and occasions during his tenure.
“His endeavours have certainly helped to move the national team forward over the last few years. We are now in a better position for that and that is all we could have asked for. The decision was amicable. We’d like to thank Iestyn for all his hard work and wish him well in his new role.
“Whilst we have spoken to people already, Wales Rugby League will now begin the formal process of appointing a new head coach. The now vacant position will no doubt interest many as we have exciting challenges ahead in the European Championships at the end of the year and an annual calendar that will lead towards the 2017 World Cup in Australia and New Zealand.”