Nathaniel Peteru is set to feature for Leeds on Friday, while Wigan have named an unchanged side.
Adrian Lam has named an unchanged Wigan Warriors side to the one that lost to St Helens in the opening game of the season last Thursday.
Morgan Escare and Taulima Tautai could feature for the Warriors after failing to make the final 17-man squad last week.
Leeds Rhinos coach Dave Furner has made two changes to his outfit that lost at Warrington Wolves last Saturday.
Peteru has recovered from a chest infection and is set to make his first appearance of the season, while outside-back Harry Newman has also been brought into the squad.
The pair replace veteran back-rower Jamie Jones-Buchanan and young forward Cameron Smith.
The televised Super League round two clash takes place at the DW Stadium on Friday, 7:45pm kick-off.
Wigan’s 19-man squad: Joe Bullock, Tony Clubb, Tom Davies, Morgan Escare, Liam Farrell, Ben Flower, Oliver Gildart, Joe Greenwood, Gabe Hamlin, Zak Hardaker, Willie Isa, Tommy Leuluai, Liam Marshall, Romain Navarrete, Sean O’Loughlin, Sam Powell, Dan Sarginson, Taulima Tautai, George Williams.
Leeds’ 19-man squad: Jack Walker, Tom Briscoe, Kallum Watkins, Konrad Hurrell, Ash Handley, Tui Lolohea, Richie Myler, Adam Cuthbertson, Matt Parcell, Brad Singleton, Trent Merrin, Stevie Ward, Brad Dwyer, Liam Sutcliffe, Brett Ferres, Nathaniel Peteru, Mikolaj Oledzki, James Donaldson, Harry Newman.