It’s a landmark occasion for the Welsh side, playing on home soil, with the chance to get the union-mad nation behind them for a World Cup that also takes in games at Wrexham and Neath, the homes of the two professional Welsh clubs.
That game, held at the Racecourse Ground, was won 13-6 by the Italians, and one of the try scorers that day, Ben Falcone, is set to start at stand-off on Saturday.
Exciting Newcastle wing Josh Mantellato, the drop goal hero last week, also played in that game three years ago.
Both sides have improved considerably since that game, with the Italians in particular adding NRL experience to their side.
Hooker Raymond Nasso, of French club Avignon, was superb in the friendly victory over England, and he has a place on the bench.
Wales‘ only warm-up game came in the shape of a comfortable 62-12 victory over a Welsh Select side.
Starting hooker Dean Parata also impressed last week, and dummy half could be where the game is won or lost.
Wales: Neil Budworth (Moranbah), Ross Divorty (York), Gil Dudson (Wigan), Jacob Emmitt (Salford), Ben Evans (Bradford), Rhys Evans (Warrington), Ben Flower (Wigan), Tyson Frizell (St George), Jordan James (Salford), Elliot Kear (Bradford), Craig Kopczak (Huddersfield), Rhodri Lloyd (Wigan), Peter Lupton (Workington), Larne Patrick (Huddersfield), Matt Seamark (Wynnum Manly), Anthony Walker (St Helens), Ian Webster (Central Queensland), Lloyd White (Widnes), Rhys Williams (Warrington).
Italy: Anthony Minichiello (Sydney), Joshua Mantellato (Newcastle), James Tedesco (Wests), Aiden Guerra (Sydney), Chris Centrone (North Sydney), Ben Falcone (Souths Logan), Ryan Ghietti (Northern Pride), Anthony Laffranchi (St Helens), Dean Parata (Parramatta), Paul Vaughan (Canberra), Mark Minichiello (Gold Coast), Cameron Ciraldo (Penrith), Joel Riethmuller (North Queensland). Interchanges (from): Sam Gardel (Souths Logan), Ryan Tramonte (Windsor), Brendan Santi (Wests), Raymond Nasso (Avignon), Tim Maccan (Tweed Heads), Gavin Hiscox (Central Queensland)