Wilkes, 35, is a former Wildcat who last played for Wakefield in 2013. Trinity have lost their last 11 Super League games, but Wilkes is taking nothing for granted.
“Obviously it’ll be a great achievement to show how far Leigh have come,” he said.
“It’s going to be a tough game, especially with them in their own backyard. I know what it’s like to win there and nobody likes to go to Wakefield.
“It’s a traditional ground where the fans are right on top of you. It’ll be very interesting.”
Wilkes also knows that a Cup tie is always a one-off, with the result determined by which team turns up with the better atttidue on the day.
“It’s a Challenge Cup tie, so it’s whoever turns up with their A game on the day who will come away with the spoils,” he said.
“Form is temporary, class is permanent. Wakefield have a good squad, and they started really well. Unfortunately for them they’ve been battered by injuries so they’ve found it really difficult to get any momentum.
“They’ve had a few high-scoring games recently, but they’ve been on the wrong side of the scorelines.”