Trent Barrett and Chris Ashton grabbed a brace of tries each to condem the Wildcats to their fourth league game without a win, which sees them fall below Wigan in the table.
David Vaealiki scored the first try on 13 minutes and two Pat Richards goals put the Warriors 8-0 in front. Ben Jeffries hit back with a try for the Wildcats, but Richards' try just before the break gave the home side a 14-4 half time advantage.
Wigan cut loose in the second half and two early tries from Trent Barrett saw off the Wakefield challenge, with Darrell Goulding grabbing a try before Ashton's late double. Jason Demetriou claimed a consolation for Wakefield.
Wigan boss Brian Noble was pleased to bounce back from last weekend's loss to the Giants. He said: "I thought we defended well all night. There are still things that we need to do right, but we were a lot more vigorous. When we're fresh we defend okay.
"I gave the back three a bit of stick through the week in relation to what we did last weekend, and they responded in the only way they possibly can.
"I thought they carried the ball strongly and got us rolling forward pretty well, and I thought they showed in broken field they're not bad."
John Kear, Wakefield's Head Coach, was complimentary of Wigan's display, but wasn't happy with his side's second half performance. He said: "Wigan were too tough, too skilful, too good. I thought our second-half performance was very poor.
"The incident that really turned the game was when Jamie Rooney put in a dangerous kick near the Wigan posts, we didn't react, and Wigan picked it up and then ended up going to the other end and scoring.
"For me, the game hinged on that, because after that they gained more and more control and had more and more ascendancy."