Wesser, 32, brings to an end a career which has spanned 14 NRL seasons in the, seen him represent Queensland and win a premiership.
Nicknamed ‘Danny Glover’ because of his likeness to the Hollywood actor, Wesser also played for the Indigenous Dream Team during the 2008 World Cup.
He spent 11 seasons with Penrith, winning a premiership with the Panthers in 2003.
Wesser says he is looking forward to starting the next chapter of his life.
“Season’s end is the right time to hang up the boots and look towards the next phase of my life,” Wesser said.
“I’ve enjoyed every minute of my career and I’ve been lucky enough to play for my state, to represent my people at the World Cup, and to have had the feeling of winning a premiership.
“I’ve been lucky enough to play with some wonderful players over the past 14 years and I’ve met a lot of great people, some of whom will be friends for life.
“I still have this season to finish off and I will give my all for the Rabbitohs on the field over these remaining games, and then I can focus on life after football.”