The former South Sydney Rabbitohs back-rower limped off in the early stages of Thursday’s 62-18 Super League win over Salford and sat out the rest of the game with an ice pack strapped to his calf.
In his pre-match press conference, head coach Steve Price confirmed that Clark, who has featured in all 10 league and cup matches so far this year, will be sidelined for around a month.
Price said: “Jace Clark has a calf strain so he’s looking at four to five weeks.
“It’s unfortunate as he was playing some really good football and was doing a lot of good things for us.
“It’s a shame for Jace but he’ll be diligent in his rehab and hopefully he won’t be too far away.
“Other than that, we’re all good and ready to go.”
Clark joins centre Greg Inglis (hamstring) and full-back or winger Matty Ashton (ankle) on the Wolves’ injury list but Price says prop Mike Cooper will be back for the semi-final at Leigh Sports Village after sitting out the trip to Salford.