Briscoe, 29, missed the opening rounds of Super League after joining in the close season from Hull KR, and he is now facing six weeks on the sidelines with a groin injury picked up in last weekend’s club record 76-6 defeat at Catalan.
Former Warrington prop Pickersgill is also set to miss up to a month after twisting his ankle in the game in France.
Coach Denis Betts said: “It doesn’t look great at times.
“And the hardest thing is that when we suffer injuries and want to bring players through – I see a group of talented kids but with no training age.
“Sides like Warrington, Wigan and St Helens have had full-time academies for a number of years. They have 19-year-olds who have been professionals for three years.
“I look and see kids who have six months under their belt, or some of the kids who are still at school and not full-time. To pitch them in at this level would be dangerous.”
They are likely to come up against half-back Gareth O’Brien, who has been named in the Warrington squad having spent the past month on loan at the Stobart Stadium.
Widnes 19-man squad v Warrington: Ah Van, Allen, Cahill, Craven, Cross, Dean, Finnigan, Flynn, Haggerty, Gerrard, Hanbury, Isa, Kite, Leuluai, Moore, Owens, Phelps, White, Winterstein.
Warrington 19-man squad v Widnes: Atkins, Blythe, Bridge, Briers, Carvell, Cooper, Currie, Dwyer, Higham, Hill, Hodgson, McCarthy, J. Monaghan, Myler, O’Brien, Riley, Westwood, Williams, Wood.