The Pool B clash follows a week after Spain’s clash with Russia, and could be decisive when it comes to shaping the outcome of the qualifying group.
“The Ireland game will not only be against our highest-level opposition in our history but it’s possibly our chance to progress through to the Antipodes next year,” said Spain head coach Darren Fisher.
“Spain is well known for the ex-pat community here and I’m sure Irish supporters will be out to enjoy the match in Valencia, it is a terrific city.
“It’s exciting to be part of the qualifying rounds, we will try not to get carried away too much in the emotion of the occasions. I will be preparing the squad for two very challenging, different styles in Russia and Ireland.
“The game has already attracted a lot of interest.”
Ireland play Russia at home on October 29, a game that they hope will seal their qualification for the 2017 tournament.
“We are really looking forward to visiting Valencia,” RLI director Richard Egan said.
“There is an air of uncertainty around the Spanish team as we haven’t faced them before, but we have seen their results and we know we will need to prepare for a tough encounter.”