12 players return for the Dragons, while the Warriors make only one change to their provisional 19 man squad.
Catalans Dragons rested 12 players in their 56-6 loss to Warrington Wolves last week.
Catalans Head Coach Steve McNamara has now announced a heavily different 19 to face Wigan.
Brayden Wiliame, Fouad Yaha, Sam Moa, Louis Anderson, Julian Bousquet, Lewis Tierney, Michael McIlorum, Benjamin Jullien, Tony Gigot, Josh Drinkwater and Kenny Edwards all return.
Warriors Head Coach Shaun Wane has made just the single change to his provisional 19 man squad that defeated Castleford Tigers last Friday.
Craig Mullen has been included at the expense of Josh Woods.
The Super 8s clash takes place at the Stade Gilbert Brutus on Saturday, 5:15pm kick-off.
Catalans Dragons 19-man squad:
Iain Thornley, Brayden Williame, Fouad Yaha, Samisoni Langi, Sam Moa, Louis Anderson, Julian Bousquet, Jason Baitieri, Michael McIlorum, Lewis Tierney, Benjamin Jullien, Lucas Albert, Antoni Maria, Alrix Da Costa, Lambert Belmas, Tony Gigot, Mickael Goudemand, Josh Drinkwater, Kenny Edwards.
Wigan Warriors 19-man squad:
John Bateman, Tony Clubb, Tom Davies, Morgan Escare, Ben Flower, Joe Greenwood, Gabe Hamlin, Willie Isa, Samy Kibula, Tommy Leuluai, Liam Marshall, Craig Mullen, Romain Navarrete, Oliver Partington, Sam Powell, Dan Sarginson, Ryan Sutton, Sam Tomkins, George Williams.
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