Winger Jamie Foster scored 24 points in the 52-6 victory over the Wildcats, but Saints ended the game with just 13 fit players.
Head coach Royce Simmons said: “We don’t know officially yet, but it looks like [Lee] Gaskell has fractured his ankle.
“[Chris] Flannery has torn a hamstring and James Graham has a sternum injury. They’re all unlikely to play over the easter period.
“Even the youngsters that have been coming in, four or five of them are out injured!”