Thomas Leuluai will captain the Exiles after Brett Hodgson withdrew through injury.
Hodgson has failed to recover from a hamstring injury, which saw the fullback leave the field prematurely for Warrington against Leeds.
Catalan Dragons’ Setaimata Sa will also miss the match against England on Saturday.
Shannon McDonnell will directly replace Hodgson, while Sia Soliola moves from the second row to the centres to replace Sa.
David Fa’alogo, who was originally brought into the squad as 18th man, will start at loose forward. while Trent Waterhouse will occupy Soliola’s original second row spot.
Widnes Vikings’ Patrick Ah Van will be the Exiles’ 18th man.
Revised Exiles team to face England
Thomas Leuluai (c)
Patrick Ah Van