Dan Sarginson and Romain Navarrete are set to return for Wigan on Thursday, while London have made two changes.
Wigan coach Adrian Lam has made one change to his Warriors side that beat Castleford last Saturday. Navarrete comes in for the injured Joe Burgess.
Sarginson and Morgan Escare could also feature for Wigan after missing out on the matchday squad against the Tigers.
Danny Ward has made two changes to his London outfit that lost to Salford last time out. Eloi Pelissier and Greg Richards replace Sam Davis and Matty Gee.
The televised Super League match takes place at the DW Stadium on Thursday, 7:45pm kick-off.
Wigan’s 19-man squad: Joe Bullock, Morgan Escare, Ben Flower, Oliver Gildart, Joe Greenwood, Chris Hankinson, Zak Hardaker, Willie Isa, Tommy Leuluai, Liam Marshall, Romain Navarrete, Sean O’Loughlin, Ollie Partington, Sam Powell, Dan Sarginson, Jake Shorrocks, Morgan Smithies, Taulima Tautai, George Williams.
London’s 19-man squad: Jordan Abdull, Sadiq Adebiyi, Eddie Battye, Robert Butler, James Cunningham, Kieran Dixon, Matt Fleming, Dan Hindmarsh, Mark Ioane, Elliot Kear, Will Lovell, Ryan Morgan, Eloi Pelissier, Jay Pitts, Greg Richards, Morgan Smith, Alex Walker, Rhys Williams, Luke Yates.