St Helens’ new signings are set to make their official debuts for the club, while Zak Hardaker is set to play his first Super League game for Wigan.
Saints coach Justin Holbrook is set to hand Super League debuts to Scotland international Lachlan Coote, Samoa forward Joseph Paulo and Fiji captain Kevin Naiqama.
England and St Helens front-rower Alex Walmsley is set to make his return to Super League after recovering from a long-term neck injury.
Meanwhile, Hardaker is poised to make his official debut in his new colours.
Warriors’ coach Adrian Lam could also give Joe Bullock a chance, with the forward impressing Lam over pre-season following his arrival from Barrow Raiders.
Dom Manfredi has not been included in Wigan’s squad due to injury, with Liam Marshall coming back into the squad.
St Helens 19-man squad: Jonny Lomax, Tommy Makinson, Kevin Naiqama, Mark Percival, Regan Grace, Theo Fages, Danny Richardson, Alex Walmsley, James Roby, Luke Thompson, Zeb Taia, Joseph Paulo, Louie McCarthy-Scarsbrook, Morgan Knowles, Kyle Amor, Dom Peyroux, Matty Lees, Jack Ashworth, Lachlan Coote.
Wigan 19-man squad: Joe Bullock, Tony Clubb, Tom Davies, Morgan Escare, Liam Farrell, Ben Flower, Oliver Gildart, Joe Greenwood, Gabe Hamlin, Zak Hardaker, Willie Isa, Tommy Leuluai, Liam Marshall, Romain Navarrete, Sean O’Loughlin, Sam Powell, Dan Sarginson, Taulima Tautai, George Williams.