St Helens are set to welcome back three regulars on Saturday, while Danny Brough will return for Wakefield.
Justin Holbrook has made four changes to his St Helens side that beat Castleford last week. Luke Thompson, Mark Percival, Louie McCarthy-Scarsbrook and Danny Richardson come back into the squad.
Kyle Amor, James Bentley and Adam Swift miss out on selection, while Theo Fages is ruled out due to concussion.
Wakefield coach Chris Chester has made two changes to his outfit that lost to Catalans last time out. Brough and Jack Croft replace injured dup David Fifita and Max Jowitt.
The televised Challenge Cup quarter-final takes place at the Totally Wicked Stadium on Saturday, 3:15pm kick-off.
Drew’s dabble: A try to be scored before 10:00 minutes is priced at 8/13.
St Helens’ 19-man squad: Jonny Lomax, Tommy Makinson, Kevin Naiqama, Mark Percival, Regan Grace, Danny Richardson, Alex Walmsley, James Roby, Luke Thompson, Zeb Taia, Joseph Paulo, Louie McCarthy-Scarsbrook, Morgan Knowles, Dom Peyroux, Matty Lees, Jack Ashworth, Aaron Smith, Lachlan Coote, Matty Costello.
Wakefield’s 19-man squad: Matty Ashurst, James Batchelor, Danny Brough, Mason Caton-Brown, Jack Croft, Jordan Crowther, Anthony England, Ryan Hampshire, Keegan Hirst, Ben Jones-Bishop, Lee Kershaw, George King, Danny Kirmond, Craig Kopczak, Reece Lyne, Jacob Miller, Tyler Randell, Kelepi Tanginoa, Kyle Wood.