Danny Richardson could return for St Helens on Friday, while Leeds could welcome back two regular first-team players.
Justin Holbrook has named an unchanged St Helens squad to the one that beat Wakefield Trinity two weeks ago. Richardson and James Bentley could feature after missing out on selection in the final matchday 17-man squad against Trinity.
Leeds Rhinos coach Dave Furner has made one change to his side that won at Salford Red Devils last weekend. James Donaldson (concussion) is replaced by Cameron Smith.
Liam Sutcliffe and Mikolaj Oledzki could make a return to action for the Rhinos though after missing their win over Salford through illness and injury respectively.
Leeds are still without Carl Ablett, Jamie Jones-Buchanan, Ashton Golding and Dom Crosby through injury.
The televised Super League clash takes place at the Totally Wicked Stadium on Friday, 7:45pm kick-off.
St Helens’ 19-man squad: Jonny Lomax, Tommy Makinson, Kevin Naiqama, Mark Percival, Regan Grace, Theo Fages, Danny Richardson, Alex Walmsley, James Roby, Luke Thompson, Zeb Taia, Joseph Paulo, Louie McCarthy-Scarsbrook, Morgan Knowles, Kyle Amor, Dom Peyroux, Matty Lees, James Bentley, Lachlan Coote.
Leeds’ 19-man squad: Jack Walker, Tom Briscoe, Kallum Watkins, Konrad Hurrell, Ash Handley, Tui Lolohea, Richie Myler, Adam Cuthbertson, Matt Parcell, Brad Singleton, Trent Merrin, Stevie Ward, Brad Dwyer, Liam Sutcliffe, Brett Ferres, Nathaniel Peteru, Mikolaj Oledzki, Cameron Smith, Harry Newman.