Five players could make their Hull KR debuts on Friday, while Danny Langtree could play his first ever Super League game.
Scotland international Danny Addy is set to play his first game for Hull KR since suffering injury in a pre-season friendly against FC last year.
Weller Hauraki, Kane Linnett, Josh Drinkwater, Jimmy Keinhorst and Mitch Garbutt are all set to make their official debuts for the Robins.
Hull FC head coach Lee Radford could hand official debuts to Danny Langtree and Matty Dawson-Jones, as well as a second debut to Jordan Thompson.
Two-time Lance Todd Trophy winner Marc Sneyd could feature in Super League for the first time since July after recovering from a knee injury.
FC will be without Albert Kelly, Liam Harris, Lewis Bienek, Josh Bowden, Chris Green, Joe Westerman and Fetuli Talanoa for the derby clash.
The round Super League match takes place at the KCOM Craven Park on Friday, 7:45pm kick-off.
Hull KR’s 19-man squad: Craig Hall, Ben Crooks, Jimmy Keinhorst, Ryan Shaw, Danny McGuire, Robbie Mulhern, Mose Masoe, Joel Tomkins, James Greenwood, Weller Hauraki, Mitch Garbutt, Tommy Lee, Chris Atkin, Junior Vaivai, Danny Addy, George Lawler, Kane Linnett, Josh Drinkwater, Will Dagger.
Hull FC’s 19-man squad: Jamie Shaul, Bureta Faraimo, Carlos Tuimavave, Josh Griffin, Marc Sneyd, Scott Taylor, Danny Houghton, Dean Hadley, Mark Minichiello, Jordan Thompson, Matty Dawson-Jones, Masi Matongo, Brad Fash, Sika Manu, Jordan Lane, Mickey Paea, Danny Langtree, Jez Litten, Danny Washbrook.