Wigan are finishing the season strongly, and Shaun Wane names an unchanged squad from the one which defeated Catalans at Millwall last weekend.
The Warriors will go level on points with Leeds at the top of the table should they beat the Airlie Birds.
Hull coach Lee Radford has to contend with a cripplingly long injury list, and has been compelled to turn to youth.
Players such as Masimbaashe Matongo and Ross Osborne are in line to make their Super League debuts.
Wigan Warriors (19-man): Bateman, Bowen, Burgess, Charnley, Clubb, Crosby, Flower, Gelling, Gildart, Manfredi, McIlorum, Mossop, O’Loughlin, Patrick, Powell, Smith, Tautai, Tomkins, Williams.
Hull FC (19-man): Abdull, Downs, Fash, Hadley, Houghton, Lineham, Logan, Matongo, Minichiello, Naughton, Osborne, Paea, Palea’aesina, Rankin, Shaul, Sneyd, Turgut, Watts.
Matty Smith needs one appearance to reach 100 for Wigan. Smith made his Warriors debut as a substitute in a 52-10 win at Wakefield on 8 July, 2012.
Super League Summary:
Last 10 meetings:
Hull FC 12, Wigan 48 (SLR23, 23/7/15)
Wigan 13, Hull FC 12 (SLR5, 13/3/15)
Wigan 56, Hull FC 10 (SLR21, 18/7/14)
Hull FC 16, Wigan 44 (SLR12, 9/5/14)
Wigan 33, Hull FC 34 (SLR26, 30/8/13)
Hull FC 0, Wigan 16 (Challenge Cup Final, 24/8/13) (at Wembley Stadium)
Hull FC 20, Wigan 28 (SLR13, 26/4/13)
Wigan 48, Hull FC 10 (SLR23, 3/8/12)
Hull FC 12, Wigan 56 (SLR12, 22/4/12)
Hull FC 16, Wigan 30 (SLR23, 29/7/11)