St Helens have made three changes ahead of Friday night and Chris Houston is back from suspension for Widnes.
Justin Holbrook has made three changes to his St Helens side that beat Wakefield Trinity last week. Adam Swift, Kyle Amor and Matty Costello come in for Ryan Morgan, Matty Smith and Jack Ashworth.
Widnes Vikings interim head coach Francis Cummins has made two changes to his side that lost at Hull FC last time out. Houston and Stefan Marsh replace Ted Chapelhow and Patrick Ah Van.
The super League clash takes place at the Totally Wicked Stadium on Friday, 8pm kick-off.
Saints 19-man squad: Lomax, Makinson, Percival, Swift, Fages, Roby, Amor, Taia, Wilkin, McCarthy-Scarsbrook, Douglas, Knowles, Thompson, Peyroux, Richardson, Grace, Lees, Barba, Costello.
Vikings 19-man squad: Hanbury, Marsh, Inu, Runciman, Mellor, Gilmore, Dudson, Gerrard, Houston, Whitley, Craven, Olbison, Wilde, Leuluai, D Walker, J Chapelhow, Heremaia, Hauraki, Buckley.
Who will take the spoils? Let us know your thoughts in the comments below.