The club will honour former player Liam Brentley, who was recently injured after being shot in Afghanistan while on patrol with the Royal Marines.
Coach Mark Aston said: “Liam is a champion. He came out of the amateur game and acquitted himself very well in the professional game.
“We’re trying to honour him. We want to remember his time as a rugby player, and also what he’s done since then. We should be proud of these people.”
Sheffield need a point to be certain of a place in this year’s play-offs. They could be boosted by a first start in six months for prop Jack Howieson, who made a successful return to action off the bench last week.
Leigh Centurions have their own target: three points from their trip to South Yorkshire would leave them as favourites to secure a top-three finish.
Centurions coach Ian Millward said: “All we can do is set the pace.”
Mick Nanyn returns for Leigh, who now have a fully fit squad. Millward added: “We will give it our best shot and see where we are after that.”