Props Ryan McDonald (arm) and David Ford (illness) are both facing up to three weeks out of action, with McDonald still awaiting results to find out whether he suffered a broken arm that would sideline him for six weeks.
Whitehaven coach Ged Stokes has doubts over six other players and is battling against a mounting injury list.
He said: “It’s going to be a major challenge for us.”
He added: “Toulouse are a good team – they showed that last year. They took a while to get used to it but they had a really strong middle part of the season.
“We know a bit more about them this time, which is a benefit, but they haven’t really got any weaknesses as far as I can see. We’re up against it but we always put in a good show when we’re facing adversity.”
However, hooker Martin Mitchall (dislocated elbow) is facing four weeks on the sidelines.