With Sam Burgess out injured and brother George named only as 19th man, Luke was the only Burgess brother to don the green and red of South Sydney in what was expected to be an exciting game.
However the Broncos blitzed the Rabbitohs, who never seriously looked like contenders to win the match in the second half.
The result cements Brisbane’s position in the NRL, but South Sydney drop to seventh in a league that separates second to eighth by four points.
Justin Hodges grabbed Brisbane’s first try shortly after the game’s quarter mark. Chris McQueen replied for the visitors shortly before half time. Adam Reynolds’ conversion gave the Rabbitohs a 6-4 lead at the break.
Alex Glenn put the Broncos back in the lead three minutes into the second half, but Souths replied quickly through Nathan Merritt.
From there it was all down hill as the Rabbitohs collapsed in the final half hour. Dale Copely, Corey Norman and Ben Te’o added more woe to Michael Maguire’s men.