The forward suffered the hamstring injury during Sunday’s 28-22 win away at Castleford.
Chris Tuson and Dom Crosby both suffered knocks in the same match but are expected to shake them off and be fit for the game.
Head coach Shaun Wane admits the side could be down to the bare-bones: “I’ll assess Lockers in our final training session.
“But he couldn’t train today and he doesn’t miss many sessions. I may have to make some changes.”
Wane continued: I’m not sure what I’m going to do if Lockers doesn’t play. When I wrote down what was happening if we get more injuries… we’re doing it tough. But nothing will change in terms of preparation and attitude.