Wests bounced back from their hammering by South Sydney last weekend to record and gritty 23-6 win over Newcastle.
Benji Marshall, Chris Lawrence, Geoff Daniela and Gareth Ellis weighed in with tries for the Tigers with the Knights only mustering a solo Ben Rogers in reply.
Cronulla upset the form guide to register a 22-18 comeback victory over Parramatta.
The Eels led 18-10 at the break thanks to tries from Jeff Robson, Daniel Mortimer and Tom Humble but Tim Smith and Paul Aiton scored second half tries to seal the points for the Sharks.
Canberra handed St George a lesson when they defeated the Dragons 22-14 at WIN Stadium.
The Raiders took a narrow 8-6 advantage at the break and turned it into an unassailable lead thanks to three scores in succession from Joel Thompson, Josh Dugan and Jarrod Croker.
The New Zealand Warriors endured a late surge from South Sydney to record an encouraging 26-24 victory.
It was nip and tuck right through the match with South Sydney heading in at half time 18-14 thanks to scores from Colin Best, Fetuli Talanoa and Rhys Wesser.
The Warriors hit back with scores from Jerome Ropati and Russell Packer and despite another score from Talanoa, the home side held out.
Penrith continue to suprise, this time by thrashing Canterbury 31-16.
Michael Gordon was the star for the Panthers, weighing in with a hat-trick of scores and five conversions to help the home side record a comfortable victory.
Josh Morris was twice denied by the video ref and despite a superb try to Bulldogs skipper Andrew Ryan, Michael Jennings set up Gordon for his third to round off the scoring.