Skolars could include two new faces in their squad. London coach James Massara confirmed the club has signed Sam Gee, a former Wigan youngster, and Kris Hodson, a back-rower who has performed well for Leeds Met University.
However, Olly Bloom is struggling to be fit after picking up a hamstring injury.
Massara said: “The Scorpions were the toughest test we’ve had so far this year.
“They played some very good football when we went to their place, and it’s fantastic that another club has emerged in South Wales. The Crusaders were instantly competitive and South Wales are exactly the same.”
He added: “We know it’s going to be tough, but last week we made a massive improvement against Oldham.
“We had lots of field position and should have done better with it, so we’re excited about this challenge and what we can achieve this week.”
Scorpions coach Anthony Seibold said: “This weekend is going to be a really tough test for our team as we reach the half-way point of the season. In many ways this is our local derby and as development areas we look closely at each other’s progress.
“I am very fond of what the Skolars are doing and have done in London. They have been big improvers in their past two performances against Workington and Oldham and their coaching staff in James Massara and Joe Mbu have done a very good job in improving the teams performances each week recently.”