Weyman missed a large part of last season after succumbing to a knee injury in the round 10 loss at Penrith.
The 28-year-old NSW Blues Origin representative has recovered however and will mark his return from a knee reconstruction in the traditional pre-season fixture with the Rabbitohs.
Dragons team mate Jack de Belin, who started in the front row during the trial clash against the North Queensland, was delighted at having Weyman back in the team.
“Michael returning to the line-up really benefits us younger players as he has a smart head for the game and helps with confidence,” de Belin told the club’s official website.
“He is a dominant player on the field and you learn a lot from him so it is good to see he has overcome his energy and training with the squad.
“The Rabbitohs are a very competitive team so it will be a good final test for the entire team ahead of the new competition season.”
The news is less positive however for full back Bronx Goodwin, who faces a four month spell on the sidelines after suffering a pectoral injury in the trial match with the Cowboys at the weekend.