McGuire, 29, is the first player to reach 200 tries since the launch of the competition in 1996, with the double century taking him just 257 games.
The previous record holder was former Leeds centre Keith Senior, who scored his 199 tries in 413 games.
McGuire made his Super League debut on July 6th 2001 in a 56-6 win over Salford.
His first Super League try came in a 34-28 defeat against Widnes on June 22nd 2002, and his first hat-trick came on March 7th 2004 in a 34-8 win over Castleford.
He set another Super League record back in 2004, when he scored five tries in a 48-24 win against Widnes, in a season where he recorded just one try less than top scorer Lesley Vainikolo.
McGuire was named in the 2004 and 2006 Super League Dream Teams, and has won five Grand Final rings.
The top 10 is:
1. Danny McGuire (Leeds 2001-present) 200
2 Keith Senior (Leeds/Sheffield, 1996-2011) 199
3 Paul Wellens (St Helens, 1998-present) 181
4 Leon Pryce (Catalan Dragons/St Helens/Bradford, 1998-present) 158
5 David Hodgson (Hull KR/Huddersfield/Salford/Wigan/Halifax, 1999-present) 153
6 Ade Gardner (St Helens, 2002-present) 142
7 Keiron Cunningham (St Helens, 1996-2010) 138
8 Lesley Vainikolo (Bradford, 2002-2007) 136
9 Kris Radlinski (Wigan, 1996-2006) 134
10 Sean Long (Hull FC/St Helens/Wigan, 1996-2011) 132
(Totals include play-off games)