Manfredi, currently facing nine to 12 months on the sidelines with an anterior cruciate ligament injury, feels that the game is too close to call.
“They’ve shown their quality all through the season, and they’re still going strong,” he told Love Rugby League.
“We’re coming right at a good time of the season, and shown some form in recent weeks.
“So I can’t really call it, it’s going to be a tough game.”
Frank-Paul Nu’uausala is one player who has joined Wigan this season, and Manfredi expects him to have a big impact on Friday night.
“He’s had massive impact,” he said.
“He’s up to full fitness now, and he’s playing some real good rugby.
“It’s frightening what he can do when he takes that ball up.”
Manfredi was named in the Super League Dream Team earlier this week, and he is readying himself for some rehabilitation over the next few months.
The winger is still on crutches, as a long time on the sidelines stretches in front of him.
“[At the moment], it’s just a bit of icing and resting, really,” he explained.
“I’m doing a little bit of weights, and getting in to see the lads.
“So it’s not too intense at the minute, but it will be soon, when I step it up.
“It’s strength stuff – after six weeks of being crutches, there’s pretty much nothing there.
“So it’s about building it up and taking my time.
“I’ll be doing a lot of speed work too, when the time is right.
“The physio staff are really good at Wigan. I’m in the right hands, so they’ll know when I’m right.”