The 26-year-old was forced to leave the action during the first half of the Wildcats’ defeat to Castleford at the weekend, only his third game for the club.
“It’s not looking good, almost certainly season ending,” Trinity coach Brian Smith told BBC Radio Leeds.
“It’s serious, sort of chest and upper arm, it’s to do with his pectoral and maybe ligaments.”
Meanwhile, the Wildcats have signed potential cover for Locke in the shape of Lee Smith, who has returned to the club from Newcastle Falcons, a rugby union outfit.
The 28-year-old utility back has joined the club until the end of the season.
“I’m really excited to be back here,” he said.
“The club have given me a great opportunity which I am very grateful for and hopefully I can reward them.”