Leeds will welcome back four regulars on Friday, while Leigh will be without ex-Rhino Ryan Bailey.
Brian McDermott will welcome back Joel Moon, Matt Parcell, Carl Ablett and Anthony Mullally on Thursday. They have lost Brett Delaney and Jack Ormondroyd to injury though.
The duo join Kallum Watkins, Liam Sutcliffe, Brad Singleton, Jamie Jones-Buchanan, Mitch Garbutt and Nathaniel Peteru on the sidelines.
Leigh head coach Kieron Purtill has made one change to his side that fell short to Toronto Wolfpack at the Summer Bash last time out. Nick Gregson comes in for Ryan Bailey.
The Challenge Cup quarter-final clash takes place at the LD Nutrition Stadium in Featherstone on Friday, 7:35pm kick-off.
Rhinos 19-man squad: Ashton Golding, Tom Briscoe, Ryan Hall, Joel Moon, Richie Myler, Adam Cuthbertson, Matt Parcell, Carl Ablett, Stevie Ward, Brad Dwyer, Anthony Mullally, Jimmy Keinhorst, Brett Ferres, Ash Handley, Jack Walker, Jordan Lilley, Cameron Smith, Mikolaj Oledzki, Josh Walters.
Centurions 19-man squad: Craig Hall, Matty Dawson-Jones, Ben Crooks, Peter Mata’utia, Rhys Evans, Ben Reynolds, Drew Hutchison, Jamie Acton, Kevin Larroyer, Bodene Thompson, Harrison Hansen, Liam Hood, Jordan Thompson, Nathan Mason, Jack Owens, Greg Richards, Nick Gregson, Micky Higham, Jordan Baldwinson.
Who will progress through to the Challenge Cup semi-finals? Let us know in the comments below.