All three were injured in the first half and were forced to come off, as the Vikings took an impressive 28-6 lead at the break.
Briscoe suffered a leg injury while Ablett and Golding picked up knee complaints. All three will be in heavy doubt for the World Club Challenge next weekend against North Queensland.
Things got worse in the second half for Leeds as the Vikings ran in try after try.
Widnes have started 2016 strongly with wins over Wakefield and the Rhinos. Written off by some, Widnes look the read deal.