Oxford coach Tony Benson is seeking an eighth win of the season to finish 2014 on a high note.
Benson’s men have secured seven wins from their 19 league fixtures this year, but have been let down by claiming a bonus point in only one of their 12 defeats.
Stags coach Troy Perkins said: “We know if we win we’re in the play-offs, but Oxford will want to finish their season on a high. The challenge is for us to build on last week’s performance.
“We’ll focus on our defence, and try to limit their attack.”
Hemel emerged 44-24 winners in a crunch clash with Gloucestershire All Golds last week.
And Perkins believes that display proved that Hemel can make an impact in the play-offs – if they qualify.
Perkins said: “It was good that in a must-win game, all the boys responded accordingly and we played some of the best stuff we have done all year.”