The 22-year-old has played in all 10 of the Black and Whites’ league and cup matches so far this year but will sit out the game at the Leigh Sports Village with a calf injury sustained in last Friday’s 34-16 defeat by St Helens.
Hull coach Hodgson says he has chosen Cator’s replacement but will not show his hand until the day of the game.
Hodgson said: “Unfortunately, it looks like we’ll lose Joe Cator. He came off with a calf complaint at the back end of the game and I don’t think he’ll be right.
“He’s been going very well for us. I’ve been happy with his progression this year and he’s played big minutes as well.
“We’ll miss him but it’s a time for someone to step in and fill that void.
“I’m confident the team we’ve got there will do our best.”