Hull have dominated Widnes in recent times, winning six of their last seven meetings.
Widnes have been poor this season, picking up just five points from 12 games and conceding nearly 30 points per game.
Hull have won three on the bounce after a couple of dodgy performances and have the firepower to cause Widnes a ton of trouble.
They won the reverse fixture 32-12 and are long odds on to repeat the trick on Sunday.
Betfred are offering 13/10 for Hull (-14) to win and that looks to be a solid wager.