Hull have had the upper-hand over St Helens recently, winning four of the last five meetings.
They were on fire at Huddersfield last weekend, romping to a 48-8 victory.
St Helens started the season with a win, but have lost their last two and are struggling to score points.
Saints were disappointing in their 16-12 defeat at home to Wakefield Trinity last Friday, and the likes of Marc Sneyd could have a field day against their shaky defence.
Hull (-12) are 13/10 at Betfred to see off St Helens and that could be the call.