The Giants went down to Saints 30-16 on Friday night at a wet Langtree Park.
But more concerning for the Yorkshire side is the fitness of three key players.
Skipper Brough is unlikely to be right for round two against Wigan while fullback Grix will be out for some time.
The Giants also lost Joe Wardle before kick off when he pulled a quad muscle. The 24-year old is expected to be on the sidelines for at least a month.