A Saints club statement said: “Lance Hohaia has informed us of his retirement from rugby league and will therefore not play for the Club again.
“Lance has been a valued and integral member of the squad for the last three-and-a-half years and we thank him for his service.
“We wish him and his family well in their life after rugby league with St Helens.”
Known for his versatility, Hohaia has played in a range of positions throughout his career, including half-back, hooker and full-back.
Hohaia’s last appearance for Saints came in the 11-8 victory over Huddersfield on April 12. He has featured eight times in Super League this season.